Victory here would see them climb to sixth – if briefly – while West Brom have humbler goals in their sights.
Slaven Bilic’s side, 19th in the standings on six points after their defeat by Newcastle, will struggle to escape the relegation zone even with a win over City. But they’ll be eyeing a huge upset anyway, given 18th Fulham were able to secure a 1-1 draw versus champions Liverpool at the weekend.
Here’s everything you need to know about the top-flight clash:
The game will kick off at 8pm BST at the Etihad Stadium.
The match will air live on Amazon Prime.
Eric Garcia’s muscle issue is set to keep him out a while longer, while Sergio Aguero is a doubt for City after his return last week gave way to an illness-related absence from the Manchester derby.
For West Brom, the injured Conor Townsend and Hal Robson-Kanu will miss out, and Sam Field is unlikely to feature due to his recent injury and positive coronavirus test result. Elsewhere, forward Matheus Pereira is suspended.
Man City: Ederson; Walker, Stones, Dias, Cancelo; Rodri, Gundogan; Sterling, De Bruyne, Torres; Gabriel Jesus
West Brom: Johnstone; Ajayi, Ivanovic, O’Shea; Furlong, Gallagher, Sawyers, Krovinovic, Diangana; Robinson, Grant
Fulham’s spirited showing to gain a point against champions Liverpool will no doubt give West Brom belief that they can get a result here, but it will be a tough task indeed. The safe bet is a comfortable City win. Man City 3-0 West Brom.